DNA HealthOxidative Stress

Endothelial Nitric Oxide Synthase

 

eNOS 894 G>T

 

eNOS

Function

eNOS Gene Detail

eNOS gene encodes for the endothelium-derived nitric oxide synthase enzyme, which catalyzes (or uncouples) nitric oxide, and plays a key role in the regulation of vascular tone and peripheral resistance. It also has vasoprotective effects by suppressing platelet aggregation, leukocyte adhesion and smooth muscle cell proliferation.

eNOS

Variant

eNOS 894 G>T

T allele affects proteolytic cleavage of the enzyme, thereby reducing nitric oxide bio-availability in the blood vessel wall. As a result, it is associated with atherosclerosis, essential hypertension, end stage renal disease and preeclampsia.

The endothelium-derived nitric oxide (NO) plays a key role in the regulation of vascular tone and peripheral vascular resistance. It also has vasoprotective effects by suppressing platelet aggregation, leukocyte adhesion and smooth muscle cell proliferation. “Impaired endothelial function, either as a consequence of reduced production/release or increased inactivation of endothelium-derived vasodilators, as well as interactions of NO with angiotensin, reactive oxygen species and oxidized lipoproteins, has detrimental functional consequences and is one of the most important cardiovascular risk factors”.

The T allele affects proteolytic cleavage of the enzyme thereby reducing nitric oxide bio-availability in the blood vessel wall and promoting atherosclerosis, as a result it is associated with atherosclerosis, essential hypertension, end-stage renal disease and preeclampsia.

The T allele has also been associated with a number of cancers.

A meta-analysis including 11 studies regarding the eNOS G984T SNP and breast cancer showed that there was a significant association with breast cancer risk in the TT versus GG genotype. In a Korean study on 509 healthy controls, and 528 patients with colorectal cancer (CRC) findings revealed that the GT and TT genotype of the 894G>T polymorphism was associated with an increased susceptibility to CRC.

GT and TT genotype individuals might show greater beneficial effects of n-3 PUFA consumption.

eNOS

Interventions

  • Increase intake of omega 3 fatty acids and dietary antioxidant sources.
  • Increase intake of foods such as spinach and beetroot that contain nitrates and are converted naturally in the body to nitric oxide.
  • Avoid all forms of smoke.
  • Engage in regular moderate intensity physical activity.

eNOS

Articles

Replication of a Gene-Diet Interaction at CD36,NOS3 and PPARG in Response to Omega-3 Fatty Acid Supplements on Blood Lipids: A Double-Blind Randomized Controlled Trial

Zeng et al, 2018.