DNA Health 

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The Genetics of Health, Part 1



DNA Health: Lipid Metabolism, Methylation and Detoxification


The following questions are based on information provided in the ‘The Genetics of Health, Part 1’ webinar. For each question select the correct answer. There is only one correct answer for each question.

1. Which statement is true with regard to nutrigenomics and nutrigenetics?

2. When interpreting and explaining genetic results to your clients, it is useful to follow the 3-3-3 rule. Which of the following three areas does this look at (in some cases there may be less or more)?

3. Which statement is false about ApoE?

4. Fill in the missing words. The presence of the ApoE4 variation increases risk for higher levels of total cholesterol and _________, higher levels of _______ and provides the _______ antioxidant capacity compared to E2 and E3 carriers.

5. What advice would you most likely recommend to someone who is an E2 carrier who also has raised triglyceride levels?

6. What advice would you most likely recommend to someone with the GG allele of PON1?

7. Which statement about methylation is false?

8. Complete the sentence. MTHFR 677T and 1298C alleles affect the enzyme activity. Decreased MTHFR enzyme activity may result in _________ homocysteine levels, _______ DNA methylation and an _______ in DNA adducts or ‘broken DNA.

9.  MTHFR677T and 1298C variants are associated with increased risk for cardiovascular disease and cancers, neural tube defects, early miscarriage, diabetic nephropathy, mood disorders and schizophrenia. Individuals with these variations have increased intake of folate and B vitamin requirements.

10. Which of the following statements is true?

11. What advice would you recommend for someone who is compound heterozygous for MTHFR and homozygous (AA allele) for COMT?

12. Which statement is false with regard to detoxification?

13. Which statement is true with regard to GSTM1?

14. A study found that in people with the null genotype for GSTM1, low intake of green leafy vegetables was linked to higher DNA adduct levels and vice versa. A large vegetable intake is encouraged in these individuals, however the green leafy veg intake did not affect DNA adduct  levels in individuals who had the present genotype.

15. Vegetables such as cruciferous vegetables contain compounds that act at a nutrigenomic level to increase the expression of detoxification enzymes. Which statement is false?

16. What advice would you most likely recommend to a high stressed individual, with a family history of heart disease and a high priority focus for lipid and inflammation (as in the DNA Health webinar example)?

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