SOD2 Gene Detail
Superoxide dismutases (SOD) play a role in the first step of managing oxidative stress and free radicals especially within the mitochondria. SODs are enzymes that catalyze the conversion of superoxide into hydrogen peroxide and oxygen. The benefit here is that hydrogen peroxide is substantially less toxic than superoxide, even although it is still a reactive radical. This reaction occurs much faster with SOD working efficiently compared to when SOD has altered function. One would then aim to support body processes so that the mildly reactive hydrogen peroxide is neutralised by CAT or GPx.
SOD2 -28 C>T
- C allele is associated with a 30-40% increased MnSOD activity leading to reduced risk for coronary artery disease (CAD) and acute myocardial infarction (AMI).
- The T allele have links to increased carotid intima-to-media thickness and were at increased risk for CAD and AMI. However, there has been links to increased cancer risk in CC individuals especially when there is lots of oxidative stress and poor dietary antioxidant intake.
- Individuals without the T variant and that have a lower consumption of fruits and vegetables, are at increased risk of developing disease, including the risk of developing certain cancers.
- SODs are metal-containing enzymes that depend on a bound manganese, copper or zinc for their antioxidant activity.
- Increase dietary intake of vegetables and fruit and ensure adequate antioxidant intake from food.
- Regular low to moderate intensity exercise increases expression of this gene.
- Ensure adequate intake of manganese, the cofactor for SOD2.
MnSOD and CAT polymorphisms modulate the effect of the Mediterranean Diet on breast cancer risk among Greek Cyp.
Kakkoura et al, 2015